林慧豪博士

研究抽象

The neural basis of nutrient-specific feeding behavior

Our lab is interested in the neural mechanism that controls nutrient-specific feeding behavior. By employing molecular biology, neurogenetics, behavior, and functional imaging techniques, we use 果蝇 as a model organism to explore the following questions:

• What is the neuronal substrate that orchestrates protein-feeding behavior?
• How are different nutrient-specific signals integrated in central circuits to regulate feeding?
• How do internal states regulate feeding through neuromodulation of different feeding circuits?

Selected Publications

• 林HH, Kuang M, Hossain I, Xuan Y, Beebe L, Shepherd AK, Rolandi M, Wang JW. A nutrient-specific gut hormone arbitrates between courtship and feeding. 自然. 2022. 632-638.
• Sethi年代, 林HH., Shepherd AK, Volkan PC, Su CY.王建伟. Social Context Enhances Hormonal Modulation of Pheromone Detection in 果蝇. 咕咕叫. 医学杂志. 2019. 29, 3887-3898.e4.
• Ng R, Salem SS, Wu ST, Wu M, 林HH, Shepherd AK, Joiner WJ, Wang JW, and Su CY. Amplification of 果蝇 Olfactory Responses by a DEG/ENaC Channel. 神经元. 2019. 104, 947-959.e5.
• 道X *, 林HH*, Lam T, Rodriguez R, Wang JW, Kubby J. Transcutical imaging with cellular and subcellular resolution. Biomed Opt Express. 2017 Mar 1;8(3):1277-1289. (* equal contribution)
• Ng R, 林HH，王建伟，苏云英. Electrophysiological Recording from 果蝇 Trichoid Sensilla in Response to Odorants of Low Volatility. J Vis Exp. 2017年7月27日;.
• 林HH*, Cao DS*, Sethi年代, Zeng Z, Chin JSR, Chakraborty TS, Shepherd AK, Nguyen CA, Yew JY, Su CY, Wang JW. Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success. 神经元. 2016 Jun 15;90(6):1272-1285. (* equal contribution)
• 研究 highlighted in “Previews” by Márcia M. Aranha, Maria Luísa Vasconcelos.” Willing and Able: The Coordination between Sexual Displays and Fertility“ in 神经元 90, 1146-1147.
• 林HH, Chu LA, Fu TF, Dickson BJ, 蒋介石在. Parallel neural pathways mediate CO2 avoidance responses in 果蝇. 科学. 2013 Jun 14;340(6138):1338-41.
• 研究 highlighted in “Perspective” by Su, C.Y，卡尔森，J.R. “Circuit logic of avoidance and attraction” in 科学 340, 1295-1297.
• 白婷婷*，陈春春*， 林HH, Chin AL, Lai JS, Lee PT, Tully T, 蒋介石在. 果蝇 ORB protein in two mushroom body output neurons is necessary for long-term memory formation. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7898-903.
• 蒋介石在, 林CY, 壮族CC, Chang嗯, 谢长廷CH, 叶连续波, Shih CT, 吴JJ, 王GT, 陈YC, 吴CC, 陈GY, Ching欧美, 李的电脑, 林CY, 林HH, 吴CC, Hsu HW, Huang YA, Chen JY, Chiang HJ, Lu CF, Ni RF, Yeh CY, Hwang JK. Three-dimensional reconstruction of brain-wide wiring networks in 果蝇 at single-cell resolution. 咕咕叫杂志. 2011 Jan 11;21(1):1-11.
• Tseng SJ, Lee YH, Chen ZH, 林HH，林燕燕，唐世生. Integration of optical clearing and optical sectioning microscopy for three-dimensional imaging of natural biomaterial scaffolds in thin sections. J Biomed Opt. 2009 Jul-Aug;14(4):044004.
• 林HH, Lai JS, Chin AL, 陈YC, 蒋介石在. A map of olfactory representation in the 果蝇 mushroom body. 细胞. 2007 Mar 23;128(6):1205-17.
• 林HH，林奕奕，蒋思安. Internal representations of smell in the 果蝇 brain. 生物医学学报. 2007年7月,14 (4):453 - 9.